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  1. The risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) is much higher than that in the general population. As its etiology is not fully understood, we performed a pilot study using...

    Authors: Romy Hansildaar, Max van Velzen, Eduard W. J. van der Vossen, Gertjan Kramer, Michael T. Nurmohamed and Johannes H. M. Levels
    Citation: Proteome Science 2025 23:4
    Content type: Research Published on:

  2. Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome that currently lacks effective biomarkers for early diagnosis and treatment. This study seeks to identify new potential biomarkers f...

    Authors: Muyashaer Abudurexiti, Salamaiti Aimaier, Nuerdun Wupuer, Dongqin Duan, Aihaidan Abudouwayiti, Meiheriayi Nuermaimaiti and Ailiman Mahemuti
    Citation: Proteome Science 2025 23:3
    Content type: Research Published on:

  3. Lysine crotonylation (Kcr) is a novel post-translational modification that is important in functional studies. However, our understanding of Kcr in the developing human fetus brain, heart, kidney, liver, and l...

    Authors: Lingyu Huang, Huaizhou Chen, Qiang Yan, Zhipeng Zeng, Yinglan Wang, Hui Guo, Wei Shi, Junjun Guo, Jingsheng Ma, Liusheng Lai, Yong Dai, Shenping Xie and Donge Tang
    Citation: Proteome Science 2025 23:2
    Content type: Research Published on:

  4. Diabetic encephalopathy (DE) is considered as one of the complications of diabetes,which is associated with cognitive impairment in the pathological process of development. Up to now, phospholipid phosphatase ...

    Authors: Qiong Xiang, Hu Lin, Jia-Sheng Tao, Chuan-Jun Fu, Li-Ni Liu, Jing Deng and Xian-Hui Li
    Citation: Proteome Science 2025 23:1
    Content type: Research Published on:

  6. Tuberculosis drug resistance contributes to the spread of tuberculosis. Immunotherapy is an effective strategy for treating tuberculosis, with the regulation of macrophage-mediated anti-tuberculosis immunity b...

    Authors: Yi-Lin Wu, Yuan-Ting Li, Gan-Bin Liu, Jin-Lin Wu, Xiao-Ran Liu, Xin-Xuan Gao, Qi-Dan Huang, Jin Liang, Jia-Yi Ouyang, Yi-Ran Ding, Jun-Yi Wu, Yuan-Bin Lu, Yu-Chi Gao, Xiao-Zhen Cai and Jun-Ai Zhang
    Citation: Proteome Science 2024 22:13
    Content type: Research Published on:

  7. Hypertensive intracerebral hemorrhage (HICH) stands out as a critical complication of primary hypertension. Consequently, investigating messenger RNA (mRNA) biomarkers becomes imperative, offering potential ta...

    Authors: Haidong Gao, Jian Zhang, Xinjun Wang, Jixin Shou, Jianye Wang and Peng Yang
    Citation: Proteome Science 2024 22:12
    Content type: Research Published on:

  8. The complexity of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) may require the simultaneous analysis of variant types of protein biomarkers to describe it more accurately. In...

    Authors: Rui Ding, Liquan Wu, Shanshan Wei, Haoran Lu, Xiaohong Qin, Xizhi Liu, Yanhua Wang, Wen Liu, Huibing Li, Baochang Luo, Teng Xie and Zhibiao Chen
    Citation: Proteome Science 2024 22:11
    Content type: Research Published on:

  9. Dirigent (DIR) genes play a key role in the development of organic products in plants. They confer conformational influence on processes that lack stereoselectivity and regioselectivity through processes that ...

    Authors: Muhammad Abu Bakar Saddique, Ge Guan, Beibei Hu, Mudassir khan, Muhammad Dawood Amjad, Sana Abbas, Zahid Hussain, Muhammad Faizan Khurram Maqsood, Xiumei Luo and Maozhi Ren
    Citation: Proteome Science 2024 22:10
    Content type: Methodology Published on:

  10. Diabetic nephropathy affects a significant proportion of individuals with diabetes, and its progression often leads to cardiovascular disease and infections before the need for renal replacement therapy arises...

    Authors: Zongchao Yu, Yongping Lu, Mengxian Zhang, Yanshan Lin, Tak-sui Wong, Baozhang Guan, Yu Meng, Bo Hu, Fan-na Liu, Lianghong Yin, Yankun Li, Han Zhang, Donge Tang and Yong Dai
    Citation: Proteome Science 2024 22:9
    Content type: Research Published on:

  11. NEK10, a serine/threonine/tyrosine kinase belonging to the NEK (NIMA-related kinases) family, has been associated with diverse cellular processes. However, no specific target pathways have been identified. Our...

    Authors: Andressa Peres de Oliveira, Claudia D. C. Navarro, Pedro Rafael F. Dias, Tania Arguello, Brittni R. Walker, Sandra R. Bacman, Lizandra Maia Sousa, Roger F. Castilho, Sílvio R. Consonni, Carlos T. Moraes and Jörg Kobarg
    Citation: Proteome Science 2024 22:8
    Content type: Research Published on:

  12. Spatial proteomics is a multidimensional technique that studies the spatial distribution and function of proteins within cells or tissues across both spatial and temporal dimensions. This field multidimensiona...

    Authors: Mengyao Wu, Huihui Tao, Tiantian Xu, Xuejia Zheng, Chunmei Wen, Guoying Wang, Yali Peng and Yong Dai
    Citation: Proteome Science 2024 22:7
    Content type: Review Published on:

  13. Patients with immunodeficiency virus-1 (HIV-1) infection are challenging to be cured completely due to the existence of HIV-1 latency reservoirs. However, the knowledge of the mechanisms and biomarkers associate...

    Authors: Lin Yin, Qimin Wang, Siyuan Liu, Jun Chen, Yujiao Zhang, Lingqing Lu, Hongzhou Lu, Zhigang Song and Lijun Zhang
    Citation: Proteome Science 2024 22:6
    Content type: Research Published on:

  16. The role of platelets in disease progression as well as the function of platelets as part of the haemostatic and immunological system in patients with liver cirrhosis is only incompletely understood. This is p...

    Authors: Nima Haji Begli, Cora Freund, Karl-Heinz Weiss, Daniel Gotthardt and Andreas Wannhoff
    Citation: Proteome Science 2024 22:3
    Content type: Research Published on:

  17. The aim of this work was to investigate the immunological effect of MENK by analyzing the protein spectrum and bioinformatics of macrophage RAW264.7, and to explore the relationship between macrophage and ferr...

    Authors: Jing Tian, Wenrui Fu, Zifeng Xie, Yuanlong Zhao, Haochen Yang and Jiafan Zhao
    Citation: Proteome Science 2024 22:2
    Content type: Research Published on:

  18. Tepary bean (Phaseolus acutifolius A. Gray) is one of the five species domesticated from the genus Phaseolus with genetic resistance to biotic and abiotic stress. To understand the mechanisms underlying drought r...

    Authors: Daniel Padilla-Chacón, Laura Campos-Patiño, Cecilia B. Peña-Valdivia, Antonio García-Esteva, José Cruz Jiménez-Galindo and Jorge Luis Pizeno-García
    Citation: Proteome Science 2024 22:1
    Content type: Research Published on:

  19. Major depressive disorder (MDD) affects more than 350 million people worldwide, and there is currently no laboratory test to diagnose it. This pilot study aimed to identify potential biomarkers in peripheral b...

    Authors: Concepción Gamboa-Sánchez, Enrique Becerril-Villanueva, Samantha Alvarez-Herrera, Gabriela Leyva-Mascareño, Sandra L. González-López, Enrique Estudillo, Alberto E. Fernández-Molina, José Miguel Elizalde-Contreras, Eliel Ruiz-May, Aldo Segura-Cabrera, Janeth Jiménez-Genchi, Lenin Pavón, Sergio Roberto Zamudio and Gilberto Pérez-Sánchez
    Citation: Proteome Science 2023 21:23
    Content type: Research Published on:

  20. Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung ti...

    Authors: Wei Wang, Wei Shi, Yinglan Wang, Yane Yang, Ping Li, Zhipeng Zeng, Wenlong Hu, Yumei Chen, Donge Tang and Yong Dai
    Citation: Proteome Science 2023 21:22
    Content type: Research Published on:

  21. Osteoarthritis (OA) is the second-commonest arthritis, but pathogenic and regulatory mechanisms underlying OA remain incompletely understood. Here, we aimed to identify the mechanisms associated with microRNA-...

    Authors: Pinpin Jiang, Dan Liang, Hang Wang, Raorao Zhou, Xianda Che, Linlin Cong, Penghua Li, Chunfang Wang, Wenjin Li, Xiaochun Wei and Pengcui Li
    Citation: Proteome Science 2023 21:21
    Content type: Research Published on:

  22. Proteins related to sperm motility and sperm morphology have an important impact on sperm function such as metabolism, motility and fertilisation etc. An understanding of the key proteins related to semen qual...

    Authors: Yaomei Wang, Yuchao Liu, Tingting Cao, Chunyuan Shi, Zili Ren and Yanling Zhao
    Citation: Proteome Science 2023 21:20
    Content type: Research Published on:

  23. Thoracic aortic aneurysm (TAA) is a cardiovascular disease with high morbidity and mortality. However, the causes and mechanisms of TAA are not fully understood. Serum exosomes from mice with TAA were used to ...

    Authors: Jia Xu, Jiacheng Liu, Yibai Qu, Linhui Jiang, Rongxin Liang, Bohai Li, Lei Li and Yong Jiang
    Citation: Proteome Science 2023 21:19
    Content type: Research Published on:

  24. End-stage renal disease (ESRD) is a condition that is characterized by the loss of kidney function. ESRD patients suffer from various endothelial dysfunctions, inflammation, and immune system defects. Lysine m...

    Authors: Ruqi Tan, Dandan Li, Nan Hu, Jing Qiu, Zhipeng Zeng, Wanxia Cai, Yafang Zhong, Xinzhou Zhang, Pearl Pai, Kang Wang, Donge Tang and Yong Dai
    Citation: Proteome Science 2023 21:18
    Content type: Research Published on:

  25. µ-Conotoxin GIIIB (µ-CTX GIIIB) is a polypeptide containing three disulfide bridges, produced by the sea snail Conus geographus. This study was aimed to explored the cytotoxic effects of µ-CTX GIIIB on mouse s...

    Authors: Han-xi Wu, Pei-min He and Rui Jia
    Citation: Proteome Science 2023 21:17
    Content type: Research Published on:

  26. The ability of the adult mammalian heart to regenerate can save the cardiac muscle from a loss of function caused by injury. Cardiomyocyte regeneration is a key aspect of research for the treatment of cardiova...

    Authors: Lizhi Hu, Minglu Liang, Qin Jiang, Youming Jie, Long Chen and Fengxiao Zhang
    Citation: Proteome Science 2023 21:16
    Content type: Research Published on:

  27. Pseudomonas aeruginosa is well known for its intrinsic ability to resist a wide range of antibiotics, thus complicates treatment. Thus, understanding the response of the pathogen to antibiotics is important for d...

    Authors: Hong Loan Ngo, Thuc Quyen Huynh, Nguyen Bao Vy Tran, Ngoc Hoa Binh Nguyen, Thi Hang Tong, Thi Truc Ly Trinh, Van Dung Nguyen, Prem Prakash Das, Teck Kwang Lim, Qingsong Lin and Thi Thu Hoai Nguyen
    Citation: Proteome Science 2023 21:15
    Content type: Research Published on:

  28. Our previous work shows that increased matrix stiffness not only alters malignant characteristics of hepatocellular carcinoma (HCC) cells, but also attenuates metformin efficacy in treating HCC cells. Here, we...

    Authors: Xiangyu Gao, Jiali Qian, Yang Zhang, Heming Wang, Jiefeng Cui and Yehong Yang
    Citation: Proteome Science 2023 21:14
    Content type: Research Published on:

  29. DCM is a common cardiomyopathy worldwide, which is characterized by ventricular dilatation and systolic dysfunction. DCM is one of the most widespread diseases contributing to sudden death and heart failure. H...

    Authors: Hongli Xiong, Zhe Zheng, Congcong Zhao, Minzhu Zhao, Qi Wang, Peng Zhang, Yongguo Li, Ying Zhu, Shisheng Zhu and Jianbo Li
    Citation: Proteome Science 2023 21:13
    Content type: Research Published on:

  30. In this study, we aimed to identify differentially expressed heat shock protein (HSP) profiles in the villi and decidua from patients with early missed abortion (EMA).

    Authors: Xiao-Fang Chen, Xiao-Qing Chen, Hai-Lian Luo, Li-Na Xia, Shu-Hui Huang and Qi Chen
    Citation: Proteome Science 2023 21:12
    Content type: Research Published on:

  31. Effective diagnostic biomarkers for aortic aneurysm (AA) that are detectable in blood tests are required because early detection and rupture risk assessment of AA can provide insights into medical therapy and ...

    Authors: Yusuke Murakami, Mitsuhiro Nishigori, Hiroaki Yagi, Tsukasa Osaki, Masaki Wakabayashi, Manabu Shirai, Cheol Son, Yutaka Iba, Kenji Minatoya, Kengo Kusano, Tsutomu Tomita, Hatsue Ishibashi-Ueda, Hitoshi Matsuda and Naoto Minamino
    Citation: Proteome Science 2023 21:11
    Content type: Research Published on:

  32. Subarachnoid haemorrhage (SAH) is one of the most severe forms of stroke in which delayed cerebral ischemia is one of the major complications. Neurointensive care aims at preventing and treating such complicat...

    Authors: Fredrik Ginstman, Bijar Ghafouri and Peter Zsigmond
    Citation: Proteome Science 2023 21:10
    Content type: Research Published on:

  33. Chronic hepatitis B is a significant public health problem and complex pathologic process, and unraveling the underlying mechanisms and pathophysiology is of great significance. Data independent acquisition ma...

    Authors: Bo Wang, Qian Zhang, Lili Wu, Cunliang Deng, Meiyan Luo, Yu Xie, Gang Wu, Wen Chen, Yunjian Sheng, Peng Zhu and Gang Qin
    Citation: Proteome Science 2023 21:9
    Content type: Research Published on:

  34. Lumbrokinase derived from earthworms, Lumbricus rubellus is known to have fibrinolytic enzymes that have potential as therapeutic drugs due to its ability to dissolve fibrin. The current study is aimed to purify ...

    Authors: Laurentia Stephani, Puji Rahayu, Debbie Retnoningrum, Maggy Thenawidjaja Suhartono, Heni Rachmawati and Raymond R. Tjandrawinata
    Citation: Proteome Science 2023 21:8
    Content type: Research Published on:

  35. We investigated differentially expressed proteins (DEPs) in human glioblastoma U87 cells after treatment with hederagenin as a therapeutic screening mechanism and provided a theoretical basis for hederagenin i...

    Authors: Yesen Zhang, Yi Han, Yuchun Shang, Xiangyu Wang and Jiwei Sun
    Citation: Proteome Science 2023 21:7
    Content type: Research Published on:

  36. Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy cancer among the malignancies of thyroid. Despite of wide usages of proteomics in PTC, the profile of acetylated proteins in PTC remain...

    Authors: Wei Wei, Yuezhang Wu, Dong-Dong Chen, Yuntao Song, Guohui Xu, Qi Shi and Xiao-Ping Dong
    Citation: Proteome Science 2023 21:6
    Content type: Research Published on:

  37. This study aims to explore the effect of an extract of Atractylodes lancea (A. lancea) on antibiotics-induced intestinal tract disorder and the probable therapeutic mechanisms employed by this extract to ameliora...

    Authors: BaiNian Zhang, Lan Bu, Hui Tian, ZhangQiang You, MingHai Zhao, Jie Tian, YuanYuan Zhang, Qian Wang, ChengJia Tan, Yu Cao, DaRen Feng and ZhenPeng Xi
    Citation: Proteome Science 2023 21:5
    Content type: Research Published on:

  38. Macrophages have a vital role in phagocytosis and antiviral effect against invading influenza viruses. Previously, we found that methionine enkephalin (MENK) inhibited influenza virus infection by upregulating...

    Authors: Wenrui Fu, Zifeng Xie, Mei Bai, Zhen Zhang, Yuanlong Zhao and Jing Tian
    Citation: Proteome Science 2023 21:4
    Content type: Research Published on:

  39. Exosomes in the body fluid are effective cell-derived membranous structures transferring various molecules to mediate intercellular communication. The expression of protein in the urinary exosomes from the col...

    Authors: Ling Ma, Haijiao Yu, Yubing Zhu, Kaiyu Xu, Aimin Zhao, Lei Ding, Hong Gao and Man Zhang
    Citation: Proteome Science 2023 21:3
    Content type: Research Published on:

  40. This study aims to decode the proteomic signature of cardiomyocytes in response to lncRNA Ftx knockdown and overexpression via proteomic analysis, and to study the biological role of lncRNA Ftx in cardiomyocyt...

    Authors: Xiangfei Sun, Ying Jiang, Qingbao Li, Qi Tan, Mingliang Dong, Bi’e Cai, Di Zhang and Qi Zhao
    Citation: Proteome Science 2023 21:2
    Content type: Research Published on:

  41. Dl-3-n-butylphthalide (NBP) is an important medial therapy for acute ischemic stroke in China. Recent studied have revealed that NBP not only rescued the loss of dopaminergic neurons in cellular and animal mod...

    Authors: Yuan Zhao, Jian Zhang, Yidan Zhang, Shuyue Li, Ya Gao, Cui Chang, Xiang Liu, Lei Xu and Guofeng Yang
    Citation: Proteome Science 2023 21:1
    Content type: Research Published on:

  42. Horticulture productivity has been increasingly restricted by heat stress from growing global warming, making it far below the optimum production capacity. As a popular ornamental cultivar of tree peony, Paeonia ...

    Authors: Jin Ma, Qun Wang, Ling-Ling Wei, Yu Zhao, Guo-Zhe Zhang, Jie Wang and Cui-Hua Gu
    Citation: Proteome Science 2022 20:18
    Content type: Research Published on:

  43. Every year, approximately 17 million people worldwide die due to coronary heart disease, with China ranking second in terms of the death toll. Myocardial ischemia-reperfusion injury (MIRI) significantly influe...

    Authors: Xiang-Mei Zhu, Yang Tan, Yu-He Shi, Qing Li, Jue Zhu, Xiang-Dan Liu and Qiao-Zhen Tong
    Citation: Proteome Science 2022 20:17
    Content type: Research Published on:

  44. Hypoxia is a risk factor for non-alcoholic fatty liver diseases, leading to permanent imbalance of liver lipid homeostasis and steatohepatitis. However, a detailed understanding of the metabolic genes and path...

    Authors: Jin Xu, Wen-jie Chen, Zhan Wang, Ming-yuan Xin, Shen-han Gao, Wen-jing Liu, Kai-kun Wang, Jing-wei Ma, Xin-zong Yan and Yan-ming Ren
    Citation: Proteome Science 2022 20:16
    Content type: Research Published on:

  45. Multi-omics technology provides a good tool to analyze the protein toxin composition and search for the potential pathogenic factors of Solenopsis invicta, under the great harm of the accelerated invasion in sout...

    Authors: Liuyang Cai, Fengling Yang, Yongfang Wang, Jishun Yang, Yina Zhu, Xueqi Ma, Juan Höfer, Yichao Wang, Yajun Ma and Liang Xiao
    Citation: Proteome Science 2022 20:15
    Content type: Research Published on:

  46. Citrate Synthase (Cs) gene mutation (locus ahL4) has been found to play an important role in progressive hearing loss of A/J mice. HEI-OC1 cells have been widely used as an in vitro system to study cellular and m...

    Authors: Xiaowen Xu, Yue Liu, Jun Luan, Rongrong Liu, Yan Wang, Yingying Liu, Ang Xu, Bingxin Zhou, Fengchan Han and Wenjing Shang
    Citation: Proteome Science 2022 20:14
    Content type: Research Published on:

  47. Understanding the molecular and cellular mechanisms involved in the pathogenesis of ocular injured induced by mustard gas can help better identify complications and discover appropriate therapies. This study a...

    Authors: Shahram Parvin, Alireza Shahriary, Hossein Aghamollaei, B. Fatemeh Nobakht M. Gh, Hasan Bagheri, Mostafa Ghanei, Seyed-Hashem Daryabari, Khosrow Jadidi and Masoud Arabfard
    Citation: Proteome Science 2022 20:13
    Content type: Research Published on:

  48. Aging is a complex biological process accompanied by a time-dependent functional decline that affects most living organisms. Omics studies help to comprehensively understand the mechanism of aging and discover...

    Authors: Jiang-Feng Liu, Yue Wu, Ye-Hong Yang, Song-Feng Wu, Shu Liu, Ping Xu and Jun-Tao Yang
    Citation: Proteome Science 2022 20:12
    Content type: Research Published on:

  49. Transforming growth factor-beta (TGF-β) signal is an important pathway involved in all stages of liver hepatocellular carcinoma (LIHC) initiation and progression. Therefore, targeting TGF- β pathway may be a p...

    Authors: Jingsheng Liao, Qi Liu, Jingtang Chen, Zhibin Lu, Huiting Mo and Jun Jia
    Citation: Proteome Science 2022 20:11
    Content type: Research Published on:

  50. Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia caused by accumulation of pulmonary fluid, which is related to inflammatory cell infiltration, impaired tight junction of pul...

    Authors: Xu-Peng Wen, Guo Long, Yue-Zhong Zhang, He Huang, Tao-Hua Liu and Qi-Quan Wan
    Citation: Proteome Science 2022 20:10
    Content type: Research Published on:
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  • Citation Impact 2023
    Journal Impact Factor: 2.1
    5-year Journal Impact Factor: 2.0
    Source Normalized Impact per Paper (SNIP): 0.430
    SCImago Journal Rank (SJR): 0.495

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ISSN: 1477-5956