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  1. The success of new sequencing technologies and informatic methods for identifying genes has made establishing gene product function a critical rate limiting step in progressing the molecular sciences. We prese...

    Authors: Michael J McGuire, Stephen A Johnston and Kathryn F Sykes
    Citation: Proteome Science 2012 10:4
    Content type: Research Published on:

  2. Studying the large-scale protein-protein interaction (PPI) network is important in understanding biological processes. The current research presents the first PPI map of swine, which aims to give new insights ...

    Authors: Fen Wang, Min Liu, Baoxing Song, Dengyun Li, Huimin Pei, Yang Guo, Jingfei Huang and Deli Zhang
    Citation: Proteome Science 2012 10:2
    Content type: Research Published on:

  3. In this study, proteomics methods have been used to study the effects of different currents and voltages used to stun chickens. Protein profiles of chicken hearts were constructed to detect differences in prot...

    Authors: Azura Amid, Norshahida A Samah and Faridah Yusof
    Citation: Proteome Science 2012 10:1
    Content type: Research Published on:

  4. Individual responses to oxaliplatin (L-OHP)-based chemotherapy remain unpredictable. The objective of our study was to find candidate protein markers for tumor sensitivity to L-OHP from intracellular proteins ...

    Authors: Sayo Suzuki, Yasuko Yamayoshi, Akito Nishimuta and Yusuke Tanigawara
    Citation: Proteome Science 2011 9:76
    Content type: Research Published on:

  5. The clinical benefits associated with targeted oncology agents are generally limited to subsets of patients. Even with favorable biomarker profiles, many patients do not respond or acquire resistance. Existing...

    Authors: Phillip Kim, Xinjun Liu, Tani Lee, Limin Liu, Robert Barham, Richard Kirkland, Glen Leesman, Anne Kuller, Belen Ybarrondo, Shi-Chung Ng and Sharat Singh
    Citation: Proteome Science 2011 9:75
    Content type: Research Published on:

  6. Propolis is a natural, resinous hive product that has several pharmacological activities. Its composition varies depending on the vegetation, climate, season and environmental conditions of the area from where...

    Authors: Yaşam Barlak, Orhan Değer, Meltem Çolak, Senem Ceren Karataylı, Abdurrahman Mithat Bozdayı and Fulya Yücesan
    Citation: Proteome Science 2011 9:74
    Content type: Research Published on:

  7. The advent of affinity-based proteomics technologies for global protein profiling provides the prospect of finding new molecular biomarkers for common, multifactorial disorders. The molecular phenotypes obtain...

    Authors: Bernet S Kato, George Nicholson, Maja Neiman, Mattias Rantalainen, Chris C Holmes, Amy Barrett, Mathias Uhlén, Peter Nilsson, Tim D Spector and Jochen M Schwenk
    Citation: Proteome Science 2011 9:73
    Content type: Research Published on:

  8. Root gravitropsim has been proposed to require the coordinated, redistribution of the plant signaling molecule auxin within the root meristem, but the underlying molecular mechanisms are still unknown. PIN pro...

    Authors: Chao Tan, Hui Wang, Yue Zhang, Bin Qi, Guoxin Xu and Huiqiong Zheng
    Citation: Proteome Science 2011 9:72
    Content type: Research Published on:

  9. The effects of fetal calf serum (FCS) heat inactivation and bacterial lipopolysaccharide (LPS) contamination on cell physiology have been studied, but their effect on the proteome of cultured cells has yet to ...

    Authors: Hazir Rahman, Muhammad Qasim, Frank C Schultze, Michael Oellerich and Abdul R Asif
    Citation: Proteome Science 2011 9:71
    Content type: Research Published on:

  10. Neutrophils are abundant leukocytes that play a primary role in defence against pathogens. Neutrophils enter sites of infection where they eliminate pathogens via phagocytosis and the release of antimicrobial ...

    Authors: Gary Eitzen, Andrea N Lo, Troy Mitchell, John D Kim, Danny V Chao and Paige Lacy
    Citation: Proteome Science 2011 9:70
    Content type: Research Published on:

  11. Chronic hemodynamic overloading leads to heart failure (HF) due to incompletely understood mechanisms. To gain deeper insight into the molecular pathophysiology of volume overload-induced HF and to identify po...

    Authors: Jiri Petrak, Jana Pospisilova, Miroslava Sedinova, Petr Jedelsky, Lucie Lorkova, Ondrej Vit, Michal Kolar, Hynek Strnad, Jan Benes, David Sedmera, Ludek Cervenka and Vojtech Melenovsky
    Citation: Proteome Science 2011 9:69
    Content type: Research Published on:

  12. The initial pharmacokinetic study of a new anticancer agent (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum (IV) (LA-12) was complemented by proteomic screening of rat plasma. The objective of the ...

    Authors: Pavel Bouchal, Jiri Jarkovsky, Kristyna Hrazdilova, Monika Dvorakova, Iva Struharova, Lenka Hernychova, Jiri Damborsky, Petr Sova and Borivoj Vojtesek
    Citation: Proteome Science 2011 9:68
    Content type: Research Published on:

  13. Mice lacking surfactant protein-A (SP-A-/-; knockout; KO) exhibit increased vulnerability to infection and injury. Although many bronchoalveolar lavage (BAL) protein differences between KO and wild-type (WT) a...

    Authors: David S Phelps, Todd M Umstead, Omar A Quintero, Christopher M Yengo and Joanna Floros
    Citation: Proteome Science 2011 9:67
    Content type: Research Published on:

  14. Butanol is a second generation biofuel produced by Clostridium acetobutylicum through acetone-butanol-ethanol (ABE) fermentation process. Shotgun proteomics provides a direct approach to study the whole proteome ...

    Authors: Kumaran Sivagnanam, Vijaya GS Raghavan, Manesh Shah, Robert L Hettich, Nathan C Verberkmoes and Mark G Lefsrud
    Citation: Proteome Science 2011 9:66
    Content type: Research Published on:

  15. Similarity search in protein databases is one of the most essential issues in computational proteomics. With the growing number of experimentally resolved protein structures, the focus shifted from sequences t...

    Authors: Jakub Galgonek, David Hoksza and Tomáš Skopal
    Citation: Proteome Science 2011 9(Suppl 1):S20
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  16. Proteins play fundamental and crucial roles in nearly all biological processes, such as, enzymatic catalysis, signaling transduction, DNA and RNA synthesis, and embryonic development. It has been a long-standi...

    Authors: Shih-Chieh Su, Cheng-Jian Lin and Chuan-Kang Ting
    Citation: Proteome Science 2011 9(Suppl 1):S19
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  17. Identifying biologically relevant protein complexes from a large protein-protein interaction (PPI) network, is essential to understand the organization of biological systems. However, high-throughput experimen...

    Authors: Shikui Tu, Runsheng Chen and Lei Xu
    Citation: Proteome Science 2011 9(Suppl 1):S18
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  18. There is a growing interest in the identification of proteins on the proteome wide scale. Among different kinds of protein structure identification methods, graph-theoretic methods are very sharp ones. Due to ...

    Authors: Yan Yan, Shenggui Zhang and Fang-Xiang Wu
    Citation: Proteome Science 2011 9(Suppl 1):S17
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  19. Protein-RNA interactions play an important role in numbers of fundamental cellular processes such as RNA splicing, transport and translation, protein synthesis and certain RNA-mediated enzymatic processes. The...

    Authors: Wei Chen, Shao-Wu Zhang, Yong-Mei Cheng and Quan Pan
    Citation: Proteome Science 2011 9(Suppl 1):S16
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  20. Protein complexes are important for understanding principles of cellular organization and functions. With the availability of large amounts of high-throughput protein-protein interactions (PPI), many algorithm...

    Authors: Guimei Liu, Chern Han Yong, Hon Nian Chua and Limsoon Wong
    Citation: Proteome Science 2011 9(Suppl 1):S15
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  21. Protein complexes are important entities to organize various biological processes in the cell, like signal transduction, gene expression, and molecular transmission. In most cases, proteins perform their intri...

    Authors: Osamu Maruyama and Ayaka Chihara
    Citation: Proteome Science 2011 9(Suppl 1):S14
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  22. Protein-protein interactions are important for several cellular processes. Understanding the mechanism of protein-protein recognition and predicting the binding sites in protein-protein complexes are long stan...

    Authors: M Michael Gromiha, N Saranya, S Selvaraj, B Jayaram and Kazuhiko Fukui
    Citation: Proteome Science 2011 9(Suppl 1):S13
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  23. Studies of intrinsically disordered proteins that lack a stable tertiary structure but still have important biological functions critically rely on computational methods that predict this property based on seq...

    Authors: Ping Zhang and Zoran Obradovic
    Citation: Proteome Science 2011 9(Suppl 1):S12
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  24. DNA-binding proteins perform their functions through specific or non-specific sequence recognition. Although many sequence- or structure-based approaches have been proposed to identify DNA-binding residues on ...

    Authors: Chien-Chih Wang and Chien-Yu Chen
    Citation: Proteome Science 2011 9(Suppl 1):S11
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  25. In proteomics studies, liquid chromatography coupled to mass spectrometry (LC-MS) has proven to be a powerful technology to investigate differential expression of proteins/peptides that are characterized by th...

    Authors: Zhiqun Tang, Lihua Zhang, Amrita K Cheema and Habtom W Ressom
    Citation: Proteome Science 2011 9(Suppl 1):S10
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  26. Transcriptional regulation by transcription factor (TF) controls the time and abundance of mRNA transcription. Due to the limitation of current proteomics technologies, large scale measurements of protein leve...

    Authors: Jia Meng, Jianqiu (Michelle) Zhang, Yidong Chen and Yufei Huang
    Citation: Proteome Science 2011 9(Suppl 1):S9
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  27. The functions of proteins are closely related to their subcellular locations. In the post-genomics era, the amount of gene and protein data grows exponentially, which necessitates the prediction of subcellular...

    Authors: Man-Wai Mak, Wei Wang and Sun-Yuan Kung
    Citation: Proteome Science 2011 9(Suppl 1):S8
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  28. Protein complexes can be identified from the protein interaction networks derived from experimental data sets. However, these analyses are challenging because of the presence of unreliable interactions and the...

    Authors: Bo Xu, Hongfei Lin and Zhihao Yang
    Citation: Proteome Science 2011 9(Suppl 1):S7
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  29. Complex intracellular signaling networks monitor diverse environmental inputs to evoke appropriate and coordinated effector responses. Defective signal transduction underlies many pathologies, including cancer...

    Authors: Javad Safaei, Ján Maňuch, Arvind Gupta, Ladislav Stacho and Steven Pelech
    Citation: Proteome Science 2011 9(Suppl 1):S6
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  30. Protein-protein interactions (PPIs) play fundamental roles in nearly all biological processes. The systematic analysis of PPI networks can enable a great understanding of cellular organization, processes and f...

    Authors: Lei Shi, Xiujuan Lei and Aidong Zhang
    Citation: Proteome Science 2011 9(Suppl 1):S5
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  31. ATP is a ubiquitous nucleotide that provides energy for cellular activities, catalyzes chemical reactions, and is involved in cellular signalling. The knowledge of the ATP-protein interactions helps with annot...

    Authors: Ke Chen, Marcin J Mizianty and Lukasz Kurgan
    Citation: Proteome Science 2011 9(Suppl 1):S4
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  32. Charge states of tandem mass spectra from low-resolution collision induced dissociation can not be determined by mass spectrometry. As a result, such spectra with multiple charges are usually searched multiple...

    Authors: Jinhong Shi and Fang-Xiang Wu
    Citation: Proteome Science 2011 9(Suppl 1):S3
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  33. Fourier Transform Mass Spectrometry coupled with Liquid Chromatography(LC-FTMS) has been widely used in proteomics. Past investigation has revealed that there exists an intensity dependent random suppression i...

    Authors: Xuepo Ma, Jian Cui and Jianqiu Zhang
    Citation: Proteome Science 2011 9(Suppl 1):S2
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  34. Previous studies on protein-DNA interaction mostly focused on the bound structure of DNA-binding proteins but few paid enough attention to the unbound structures. As more new proteins are discovered, it is use...

    Authors: Weiqiang Zhou and Hong Yan
    Citation: Proteome Science 2011 9(Suppl 1):S1
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  35. Proteome analysis is frequently applied in identifying the proteins or biomarkers in knee synovial fluids (SF) that are associated with osteoarthritis and other arthritic disorders. The 2-dimensional gel elect...

    Authors: Carl PC Chen, Chih-Chin Hsu, Wen-Lin Yeh, Hsiu-Chu Lin, Sen-Yung Hsieh, Shih-Cherng Lin, Tai-Tzung Chen, Max JL Chen and Simon FT Tang
    Citation: Proteome Science 2011 9:65
    Content type: Research Published on:

  36. Refractory cytopenia with multilineage dysplasia (RCMD) is a subgroup of myelodysplastic syndrome (MDS), which belongs to oncohematological diseases, occurring particularly in elderly patients, and represents ...

    Authors: Pavel Májek, Zuzana Reicheltová, Jiří Suttnar, Jaroslav Čermák and Jan E Dyr
    Citation: Proteome Science 2011 9:64
    Content type: Research Published on:

  37. Hodgkin lymphoma (HL) represents a category of lymphoid neoplasms with unique features, notably the usual scarcity of tumour cells in involved tissues. The most common subtype of classical HL, nodular sclerosi...

    Authors: Philippe Kischel, David Waltregny, Yannick Greffe, Gabriel Mazzucchelli, Edwin De Pauw, Laurence de Leval and Vincent Castronovo
    Citation: Proteome Science 2011 9:63
    Content type: Research Published on:

  38. Protein enrichment by sub-cellular fractionation was combined with differential-in-gel-electrophoresis (DIGE) to address the detection of the low abundance chromatin proteins in the budding yeast proteome. Com...

    Authors: Dong Ryoung Kim, Rohan D Gidvani, Brian P Ingalls, Bernard P Duncker and Brendan J McConkey
    Citation: Proteome Science 2011 9:62
    Content type: Research Published on:

  40. A recent epidemiological study demonstrated a reduced risk of lung cancer mortality in breast cancer patients using antiestrogens. These and other data implicate a role for estrogens in lung cancer, particular...

    Authors: MM Ivanova, SM Abner, WM Pierce Jr and CM Klinge
    Citation: Proteome Science 2011 9:60
    Content type: Research Published on:

  41. Parkinson's disease (PD) is histologically well defined by its characteristic degeneration of dopaminergic neurons in the substantia nigra pars compacta. Remarkably, divergent PD-related mutations can generate co...

    Authors: Madeleine Diedrich, Tohru Kitada, Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose and Lei Mao
    Citation: Proteome Science 2011 9:59
    Content type: Research Published on:

  42. Xylella fastidiosa is limited to the xylem of the plant host and the foregut of insect vectors (sharpshooters). The mechanism of pathogenicity of this bacterium differs from other plant pathogens, since it does ...

    Authors: Mariana S Silva, Alessandra A De Souza, Marco A Takita, Carlos A Labate and Marcos A Machado
    Citation: Proteome Science 2011 9:58
    Content type: Research Published on:

  43. Mycophenolic acid (MPA) is widely used as a post transplantation medicine to prevent acute organ rejection. In the present study we used proteomics approach to identify proteome alterations in human embryonic ...

    Authors: Muhammad Qasim, Hazir Rahman, Michael Oellerich and Abdul R Asif
    Citation: Proteome Science 2011 9:57
    Content type: Research Published on:

  44. Prenatal screening for Down Syndrome (DS) would benefit from an increased number of biomarkers to improve sensitivity and specificity. Improving sensitivity and specificity would decrease the need for potentia...

    Authors: Wendy E Heywood, Tracey E Madgett, Darrell Wang, Amanda Wallington, Julie Hogg, Kevin Mills and Neil D Avent
    Citation: Proteome Science 2011 9:56
    Content type: Research Published on:

  45. Non Small Cell Lung Cancer (NSCLC) is the major cause of cancer related-death. Many patients receive diagnosis at advanced stage leading to a poor prognosis. At present, no satisfactory screening tests are ava...

    Authors: Emanuela Monari, Christian Casali, Aurora Cuoghi, Jessica Nesci, Elisa Bellei, Stefania Bergamini, Luca I Fantoni, Pamela Natali, Uliano Morandi and Aldo Tomasi
    Citation: Proteome Science 2011 9:55
    Content type: Research Published on:

  46. Follicular fluid accumulates into the antrum of follicle from the early stage of follicle development. Studies on its components may contribute to a better understanding of the mechanisms underlying follicular...

    Authors: Somayyeh Fahiminiya, Valérie Labas, Stéphane Roche, Jean-Louis Dacheux and Nadine Gérard
    Citation: Proteome Science 2011 9:54
    Content type: Research Published on:

  47. An improved version of quantitative protein array platform utilizing linear Quantum dot signaling for systematically measuring protein levels and phosphorylation states is presented. The signals are amplified ...

    Authors: Xiaoyu Wang, Ying Dong, Ameena J Jiwani, Yonglong Zou, Johanne Pastor, Makoto Kuro-o, Amyn A Habib, Minzi Ruan, David A Boothman and Chin-Rang Yang
    Citation: Proteome Science 2011 9:53
    Content type: Methodology Published on:

  48. Phytophthora sojae causes soybean root and stem rot, resulting in an annual loss of 1-2 billion US dollars in soybean production worldwide. A proteomic technique was used to determine the effects on soybean hypo...

    Authors: YuMei Zhang, JinMing Zhao, Yang Xiang, XiaoChun Bian, QiaoMei Zuo, Qi Shen, JunYi Gai and Han Xing
    Citation: Proteome Science 2011 9:52
    Content type: Research Published on:

  49. The spontaneous metamorphosis of the polychaete Capitella sp. I larvae into juveniles requires minor morphological changes, including segment formation, body elongation, and loss of cilia. In this study, we inves...

    Authors: Kondethimmanahalli H Chandramouli, Lisa Soo and Pei-Yuan Qian
    Citation: Proteome Science 2011 9:51
    Content type: Research Published on:

  50. Identification of secreted proteins of low abundance is often limited by abundant and high molecular weight (MW) proteins. We have optimised a procedure to overcome this limitation.

    Authors: Sarah Paule, Katie Meehan, Adam Rainczuk, Andrew N Stephens and Guiying Nie
    Citation: Proteome Science 2011 9:50
    Content type: Methodology Published on:
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  • Citation Impact 2023
    Journal Impact Factor: 2.1
    5-year Journal Impact Factor: 2.0
    Source Normalized Impact per Paper (SNIP): 0.430
    SCImago Journal Rank (SJR): 0.495

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ISSN: 1477-5956