Table 2 Advancements in the Application of Spatial Proteomics in Cancer Research
Disease Type | Protein Name and location | References |
|---|---|---|
Bladder cancer | AHNAK2 (high-grade bladder cancer zone) | [56] |
Ovarian cancer | NNMT (fibroblast area of ovarian cancer stroma) | [4] |
Non-small cell lungcancer | VISTA(tumor area), SFPQ (nuclear area of tumor patient’s mesenchymal stem cells), B7-H3、GITR、PTEN、PD- (tumor area) | |
Breast cancer | α-SMA (in vitro breast cancer stroma) PD-L1、B7H3、LAG3 (primary tumor region) | |
Glioblastoma | ALCAM, ANXA11, AltProt, IP_652563RPS14 (tumor region B) PPP1R12A、RPS14 (tumor region A) SERPINA6 (peripheral blood) | |
Hepatocellular carcinoma | PD-L1 (tumor margin) | [83] |
Head and neck squamous cell carcinoma | B2M (tumor area) | [84] |
Gastric cancer | PD-L1 (tumor area) | [85] |
Esophageal cell carcinoma | IDO1 (tumor microenvironment zone) | [86] |
Endometrial cancer | RSS3 (stage 3 zone of endometrial cance), ASS1 (stage2zone of endometrial cance), ALDH2, ANXA1 (stage 1.zone of endometrial cance) | [6] |