Fig. 3
From: Phosphoproteome profiling of mouse liver during normal aging

Construction of phosphorylation-associated pathway network in mouse liver at different ages. AÂ Predicted kinase activity based on NetworKIN was mapped to a human kinome tree. BÂ Kinase-substrate interactions among the proteins with differentially expressed phosphosites were constructed based on PhosphoSitePlus using Cytoscape software. CÂ Enriched KEGG pathways for proteins with upregulated phosphosites. DÂ Enriched KEGG pathways for proteins with downregulated phosphosites